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KMID : 1145520180040020045
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Journal of Radiopharmaceuticals and Molecular Probes
2018 Volume.4 No. 2 p.45 ~ p.50
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Synthesis of oleyl-4[131I]-iodobenzoate for long-term cell trafficking
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Jeon Hak-Rim
Lee Woong-Hee
Oh Ji-Eun
Lee Yong-Jin
Yoo Jeong-Soo
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Abstract
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Great efforts are currently devoted to the development of new approaches for the labeling of cells using appropriate radionuclides. While fluoride-18 and copper-64 have been extensively studied as short-term and intermediate-term trafficking agents, iodide was studied less intensely. Here, we report a new cell labeling agent labeled with 131I , [131I]oleyl-4-iodobenzoate ([131I]OIB) for long-term cell trafficking. A precursor of [131I]OIB was obtained in two steps, with the yield of 35%. The radiochemical yield of [131I]OIB was over 50%. While [131I] OIB could label different cells, L6 cells showed the highest cell-labeling efficiency. The [131I]OIB-labeled L6 cells were imprinted into a rat heart, and then monitored noninvasively for 2 weeks by gamma camera imaging. We conclude that [131I]OIB is a good candidate molecule for a long-term cell trafficking agent.
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KEYWORD
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Radiotracer , Cell trafficking agent, I-131 , Gamma camera imaging
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